• 基因名称：
• ADD1/ADD2

• Human Swiss Prot No：
• P35611/P35612

• 储存：
• 2-8°C/6 months

• 检测方法：
• Colorimetric

• 背景：
• alternative products:Additional isoforms seem to exist,domain:Each subunit is comprised of three regions: a NH2-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region.,function:Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.,PTM:The N-terminus is blocked.,similarity:Belongs to the aldolase class II family. Adducin subfamily.,subunit:Heterodimer of an alpha and a beta subunit or an alpha and a gamma subunit. Binds ROCK1.,tissue specificity:Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit.,

• 功能：
• cell morphogenesis, in utero embryonic development, tissue homeostasis, immune system development, cell volume homeostasis, cytoskeleton organization, actin filament organization, regulation of actin polymerization or depolymerization, embryonic development ending in birth or egg hatching, negative regulation of organelle organization, cellular homeostasis, hemoglobin metabolic process, actin filament-based process, actin cytoskeleton organization, hemopoiesis, myeloid cell differentiation, erythrocyte differentiation, regulation of actin filament length,regulation of actin filament polymerization, regulation of actin filament depolymerization, negative regulation of actin filament depolymerization, negative regulation of actin filament polymerization, negative regulation of protein complex assembly, positive regulation of protein binding, regulation of protein polymerization, negative r

• 细胞定位：
• Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

• 组织表达：
• Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit.

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