Total HMG-1 Cell-Based Colorimetric ELISA Kit

  • 货号：KA3530C
  • 应用：ELISA
  • 种属：Human;Mouse;Rat
    • 基因名称：
    • HMGB1
    • Human Gene Id：
    • 3146
    • Human Swiss Prot No：
    • P09429
    • Mouse Swiss Prot No：
    • P63158
    • 储存：
    • 2-8°C/6 months
    • 其他名称：
    • High mobility group protein B1 (High mobility group protein 1) (HMG-1)
    • 检测方法：
    • Colorimetric
    • 背景：
    • function:Binds preferentially single-stranded DNA and unwinds double stranded DNA.,similarity:Belongs to the HMGB family.,similarity:Contains 2 HMG box DNA-binding domains.,
    • 功能：
    • negative regulation of transcription from RNA polymerase II promoter, DNA metabolic process, DNA replication, DNA-dependent DNA replication, DNA ligation, DNA unwinding during replication, DNA repair, base-excision repair, base-excision repair, DNA ligation, DNA recombination, chromatin organization, regulation of transcription, DNA-dependent,regulation of transcription from RNA polymerase II promoter, anti-apoptosis, response to DNA damage stimulus,negative regulation of biosynthetic process, negative regulation of macromolecule biosynthetic process, negative regulation of macromolecule metabolic process, negative regulation of gene expression, regulation of cell death,negative regulation of transcription, negative regulation of transcriptional preinitiation complex assembly, negative regulation of cellular biosynthetic process, DNA geometric change, DNA duplex unwinding, cellular respo
    • 细胞定位：
    • Nucleus . Chromosome . Cytoplasm . Secreted . Cell membrane ; Peripheral membrane protein ; Extracellular side . Endosome . Endoplasmic reticulum-Golgi intermediate compartment . In basal state predominantly nuclear. Shuttles between the cytoplasm and the nucleus (PubMed:12231511, PubMed:17114460). Translocates from the nucleus to the cytoplasm upon autophagy stimulation (PubMed:20819940). Release from macrophages in the extracellular milieu requires the activation of NLRC4 or NLRP3 inflammasomes (By similarity). Passively released to the extracellular milieu from necrotic cells by diffusion, involving the fully reduced HGMB1 which subsequently gets oxidized (PubMed:19811284). Also released from apoptotic cells (PubMed:16855214, PubMed:18631454). Active secretion from a variety of immune a
    • 组织表达：
    • Ubiquitous. Expressed in platelets (PubMed:11154118).

    Expression pattern of HMGB1 and its association with autophagy in acute necrotizing pancreatitis. Molecular Medicine Reports Mol Med Rep. 2016 Dec;14(6):5507-5513 ELISA Rat Serum
    货号：KA3530C

    Spatial and temporal differences of HMGB1 expression in the pancreas of rats with acute pancreatitis. International Journal of Clinical and Experimental Pathology Int J Clin Exp Patho. 2015; 8(6): 6928–6935 ELISA Rat serum
    货号：KA3530C

    HMGB1 binding to receptor for advanced glycation end products enhances inflammatory responses of human bronchial epithelial cells by activating p38 MAPK and ERK1/2. MOLECULAR AND CELLULAR BIOCHEMISTRY Mol Cell Biochem. 2015 Jul;405(1):63-71 ELISA Human HBECs
    货号：KA3530C

    相关报价

    • 货号：
    • KA3530C
    • 规格：
    • 96 / well
    • 价格：
    • ¥3300
    • 货期：
    • 预计发货时间为
      2024-12-10
    订购

    相关产品