Total SAE1 Cell-Based Colorimetric ELISA Kit
- 货号：KA3401C
- 应用：ELISA
- 种属：Human;Mouse;Rat
- 其他名称：
- SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A)
- 背景：
- function:The dimeric enzyme acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins and formation of a thioester with a conserved cysteine residue on SAE2.,pathway:Protein modification; protein sumoylation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the ubiquitin-activating E1 family.,subunit:Heterodimer of SAE1 and SAE2. The complex binds SUMO proteins via SAE2.,tissue specificity:Expression level increases during S phase and drops in G2 phase (at protein level).,
- 功能：
- proteolysis, macromolecule catabolic process, protein ubiquitination, modification-dependent protein catabolic process,protein catabolic process, protein modification by small protein conjugation, modification-dependent macromolecule catabolic process, cellular protein catabolic process, cellular macromolecule catabolic process, proteolysis involved in cellular protein catabolic process, protein modification by small protein conjugation or removal,
- 组织表达：
- Expression level increases during S phase and drops in G2 phase (at protein level).
