• 靶点：
• SAE1

• 简介：
• >>Ubiquitin mediated proteolysis

• 基因名称：
• SAE1

• 蛋白名称：
• SUMO-activating enzyme subunit 1

• Human Gene Id：
• 10055

• Human Swiss Prot No：
• Q9UBE0

• Mouse Gene Id：
• 56459

• Mouse Swiss Prot No：
• Q9R1T2

• Rat Gene Id：
• 308384

• Rat Swiss Prot No：
• Q6AXQ0

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human AOS1. AA range:221-270

• 特异性：
• SAE1 Polyclonal Antibody detects endogenous levels of SAE1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• SAE1;AOS1;SUA1;UBLE1A;SUMO-activating enzyme subunit 1;Ubiquitin-like 1-activating enzyme E1A

• 实测条带：
• 38kD

• 背景：
• SUMO1 activating enzyme subunit 1(SAE1) Homo sapiens Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010],

• 功能：
• function:The dimeric enzyme acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins and formation of a thioester with a conserved cysteine residue on SAE2.,pathway:Protein modification; protein sumoylation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the ubiquitin-activating E1 family.,subunit:Heterodimer of SAE1 and SAE2. The complex binds SUMO proteins via SAE2.,tissue specificity:Expression level increases during S phase and drops in G2 phase (at protein level).,

• 细胞定位：
• Nucleus .

• 组织表达：
• Expression level increases during S phase and drops in G2 phase (at protein level).

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