Total iNOS Cell-Based Colorimetric ELISA Kit
- 货号：KA3312C
- 应用：ELISA
- 种属：Human
- 其他名称：
- Nitric oxide synthase, inducible (EC 1.14.13.39) (Hepatocyte NOS) (HEP-NOS) (Inducible NO synthase) (Inducible NOS) (iNOS) (NOS type II) (Peptidyl-cysteine S-nitrosylase NOS2)
- 背景：
- catalytic activity:L-arginine + n NADPH + n H(+) + m O(2) = citrulline + nitric oxide + n NADP(+).,cofactor:Binds 1 FAD.,cofactor:Binds 1 FMN.,cofactor:Heme group.,cofactor:Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme.,enzyme regulation:Regulated by calcium/calmodulin. Aspirin inhibits expression and function of this enzyme and effects may be exerted at the level of translational/post-translational modification and directly on the catalytic activity.,function:Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions.,induction:By endotoxins and cytokines.,online information:Nitric oxide synthase entry,similarity:Belongs to the NOS family.,similarity:Contains 1 FAD-binding FR-type domain.,similarity:Contains 1 flavodoxin-like domain.,subunit:Homodimer. Binds SLC9A3R1.,tissue specificity:Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets.,
- 功能：
- blood vessel development, response to hypoxia, regulation of leukocyte mediated cytotoxicity, positive regulation of leukocyte mediated cytotoxicity, endothelial cell proliferation, vasculature development, blood vessel remodeling,innate immune response in mucosa, organ or tissue specific immune response, mucosal immune response, positive regulation of immune system process, regulation of immune effector process, positive regulation of immune effector process, regulation of peptide secretion, circulatory system process, arginine metabolic process, arginine catabolic process, oxygen and reactive oxygen species metabolic process, superoxide metabolic process, nitric oxide biosynthetic process, defense response, immune response, cell surface receptor linked signal transduction, G-protein coupled receptor protein signaling pathway, G-protein signaling, coupled to cyclic nucleotide second mes
- 细胞定位：
- Cytoplasm, cytosol . Localizes as discrete foci scattered throughout the cytosol and in the presence of SPSB1 and SPSB4, exhibits a more diffuse cytosolic localization. .
- 组织表达：
- Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets. Expressed in chondrocytes (PubMed:7504305).
