Total Cytokeratin 20 Cell-Based Colorimetric ELISA Kit

  • 货号：KA3307C
  • 应用：ELISA
  • 种属：Human;Mouse;Rat
    • 基因名称：
    • KRT20
    • Human Swiss Prot No：
    • P35900
    • Mouse Swiss Prot No：
    • Q9D312
    • 储存：
    • 2-8°C/6 months
    • 其他名称：
    • Keratin, type I cytoskeletal 20 (Cytokeratin-20) (CK-20) (Keratin-20) (K20) (Protein IT)
    • 检测方法：
    • Colorimetric
    • 背景：
    • developmental stage:First detected at embryonic week 8 in individual 'converted' simple epithelial cells of the developing intestinal mucosa. In later fetal stages, synthesis extends over most goblet cells and a variable number of villus enterocytes. In the developing gastric and intestinal mucosa, expressed in all enterocytes and goblet cells as well as certain 'low-differentiated' columnar cells, whereas the neuroendocrine and Paneth cells are negative.,function:Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine.,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).,PTM:Hyperphosphorylation at Ser-13 occurs during the early stages of apoptosis but becomes less prominent during the later stages. Phosphorylation at Ser-13 also increases in response to stress brought on by cell injury.,PTM:Proteolytically cleaved by caspases during apoptosis. Cleavage occurs at Asp-228.,similarity:Belongs to the intermediate filament family.,subunit:Heterotetramer of two type I and two type II keratins. Associates with KRT8.,tissue specificity:Expressed predominantly in the intestinal epithelium. Expressed in luminal cells of colonic mucosa. Also expressed in the Merkel cells of keratinized oral mucosa; specifically at the tips of some rete ridges of the gingival mucosa, in the basal layer of the palatal mucosa and in the taste buds of lingual mucosa.,
    • 功能：
    • apoptosis, cytoskeleton organization, cell death, programmed cell death, death, regulation of protein localization,cellular response to stress, intermediate filament-based process, intermediate filament cytoskeleton organization,intermediate filament organization, regulation of protein secretion, regulation of secretion, regulation of protein transport, regulation of cellular localization, regulation of establishment of protein localization,
    • 细胞定位：
    • Cytoplasm .
    • 组织表达：
    • Expressed predominantly in the intestinal epithelium. Expressed in luminal cells of colonic mucosa. Also expressed in the Merkel cells of keratinized oral mucosa; specifically at the tips of some rete ridges of the gingival mucosa, in the basal layer of the palatal mucosa and in the taste buds of lingual mucosa.

    相关报价

    • 货号：
    • KA3307C
    • 规格：
    • 96 / well
    • 价格：
    • ¥3300
    • 货期：
    • 预计发货时间为
      2024-08-03
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