Phospho EPB41 (Y660/418) Cell-Based Colorimetric ELISA Kit

  • 货号：KA1748C
  • 应用：ELISA
  • 种属：Human;Mouse
    • 基因名称：
    • EPB41
    • Human Gene Id：
    • 2035
    • Human Swiss Prot No：
    • P11171
    • Mouse Swiss Prot No：
    • P48193
    • 储存：
    • 2-8°C/6 months
    • 其他名称：
    • Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1)
    • 检测方法：
    • Colorimetric
    • 背景：
    • disease:Defects in EPB41 are a cause of hereditary pyropoikilocytosis (HPP) [MIM:266140]. HPP is an autosomal recessive hematologic disorder characterized by hemolytic anemia, microspherocytosis, poikilocytosis, and an unusual thermal sensitivity of red cells.,disease:Defects in EPB41 are the cause of elliptocytosis type 1 (EL1) [MIM:611804]. EL1 is a Rhesus-linked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant, hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape.,function:Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes.,PTM:O-glycosylated; contains N-acetylglucosamine side chains in the C-terminal domain.,PTM:Phosphorylated at multiple sites by different protein kinases and each phosphorylation event selectively modulates the protein's functions.,PTM:Phosphorylation on Tyr-660 reduces the ability of 4.1 to promote the assembly of the spectrin/actin/4.1 ternary complex.,similarity:Contains 1 FERM domain.,subunit:Binds with a high affinity to glycophorin and with lower affinity to band III protein. Associates with the nuclear mitotic apparatus. Binds calmodulin, CENPJ and DLG1. Also found to associate with contractile apparatus and tight junctions.,
    • 功能：
    • circulatory system process, cytoskeleton organization, blood circulation, actin filament-based process, actin cytoskeleton organization, cortical cytoskeleton organization, cortical actin cytoskeleton organization, positive regulation of protein binding, regulation of protein binding, positive regulation of molecular function, regulation of binding, positive regulation of binding,
    • 细胞定位：
    • Cytoplasm, cytoskeleton . Cytoplasm, cell cortex . Nucleus .

    相关报价

    • 货号：
    • KA1748C
    • 规格：
    • 96 / well
    • 价格：
    • ¥4700
    • 货期：
    • 预计发货时间为
      2024-12-08
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