• Target：
• TRP2

• Fields：
• >>Tyrosine metabolism;>>Metabolic pathways;>>Melanogenesis

• Gene Name：
• DCT

• Protein Name：
• L-dopachrome tautomerase

• Human Gene Id：
• 1638

• Human Swiss Prot No：
• P40126

• Mouse Gene Id：
• 13190

• Mouse Swiss Prot No：
• P29812

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human DCT. AA range:51-100

• Specificity：
• TRP2 Polyclonal Antibody detects endogenous levels of TRP2 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• DCT;TYRP2;L-dopachrome tautomerase;DCT;DT;L-dopachrome Delta-isomerase;Tyrosinase-related protein 2;TRP-2;TRP2

• Observed Band(KD)：
• 60kD

• Background：
• catalytic activity:L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.,cofactor:Binds 2 zinc ions per subunit.,function:Involved in regulating eumelanin and phaeomelanin levels.,pathway:Pigment biosynthesis; melanin biosynthesis.,similarity:Belongs to the tyrosinase family.,subunit:Tyrosinase, TYRP1 and TYRP2 may form a multienzyme complex.,

• Function：
• catalytic activity:L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.,cofactor:Binds 2 zinc ions per subunit.,function:Involved in regulating eumelanin and phaeomelanin levels.,pathway:Pigment biosynthesis; melanin biosynthesis.,similarity:Belongs to the tyrosinase family.,subunit:Tyrosinase, TYRP1 and TYRP2 may form a multienzyme complex.,

• Subcellular Location：
• Melanosome membrane ; Single-pass type I membrane protein . Melanosome . Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38. .

• Expression：
• Liver,Lymphnode melanoma metastases,Mammary gland,Melanoma,

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