• Target：
• CD57

• Gene Name：
• B3GAT1 GLCATP

• Protein Name：
• Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 (EC 2.4.1.135) (Beta-1,3-glucuronyltransferase 1) (Glucuronosyltransferase P) (GlcAT-P) (UDP-GlcUA:glycoprotein beta-1,3-glucuronylt

• Human Gene Id：
• 27087

• Human Swiss Prot No：
• Q9P2W7

• Immunogen：
• Purified recombinant Human CD57

• Specificity：
• This recombinant monoclonal antibody can detects endogenous levels of CD57 protein.

• Formulation：
• Phosphate-buffered solution

• Source：
• Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell

• Dilution：
• ELISA 1:5000-100000

• Purification：
• Recombinant Expression and Affinity purified

• Concentration：
• Please check the information on the tube

• Storage Stability：
• -15°C to -25°C/1 year(Avoid freeze / thaw cycles)

• Other Name：
• B3GAT1;GLCATP;Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1;Beta-1;3-glucuronyltransferase 1;Glucuronosyltransferase P;GlcAT-P;UDP-GlcUA:glycoprotein beta-1;3-glucuronyltransferase;GlcUAT-P;CD57 nanobody;

• Background：
• The protein encoded byThis gene is a member of the glucuronyltransferase gene family. These enzymes exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages.This gene product functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (human natural killer-1, also known as CD57 and LEU7). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

• Function：
• catalytic activity:UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein.,cofactor:Manganese.,Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group.,online information:GlycoGene database,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosy

• Subcellular Location：
• [Isoform 1]: Golgi apparatus membrane ; Single-pass type II membrane protein . Secreted .; [Isoform 2]: Golgi apparatus membrane ; Single-pass type II membrane protein . Endoplasmic reticulum membrane . Secreted .

• Expression：
• Mainly expressed in the brain.

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