CD269/BCMA (PN0553) Nb-FC recombinant antibody
- Catalog No.:YA0222
- Applications:FCM;ELISA
- Reactivity:Human
- Target:
- CD269/BCMA
- Gene Name:
- TNFRSF17 BCM BCMA
- Protein Name:
- Tumor necrosis factor receptor superfamily member 17 (B-cell maturation protein) (CD antigen CD269)
- Human Gene Id:
- 608
- Human Swiss Prot No:
- Q02223
- Immunogen:
- Purified recombinant Human CD269
- Specificity:
- This recombinant monoclonal antibody can detects endogenous levels of CD269/BCMA protein.
- Formulation:
- Phosphate-buffered solution
- Source:
- Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
- Dilution:
- ELISA 1:5000-100000;FCM 1-2μg/Test
- Purification:
- Recombinant Expression and Affinity purified
- Concentration:
- Please check the information on the tube
- Storage Stability:
- -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
- Other Name:
- TNFRSF17;BCM;BCMA;Tumor necrosis factor receptor superfamily member 17;B-cell maturation protein;CD269;CD269 nanobody;BCMA nanobody;
- Background:
- The protein encoded byThis gene is a member of the TNF-receptor superfamily.This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response.This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation.This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]
- Function:
- disease:A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.,Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.,similarity:Contains 1 TNFR-Cys repeat.,subcellular location:Perinuclear Golgi-like structures.,subunit:Associates with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6.,tissue specificity:Expressed in mature B-cells, but not in T-cells or monocytes.,
- Subcellular Location:
- Cell membrane; Single-pass type III membrane protein. Endomembrane system; Single-pass type III membrane protein. Perinuclear Golgi-like structures.
- Expression:
- Expressed in mature B-cells, but not in T-cells or monocytes.
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