CD269/BCMA (PN0553) Nb-FC recombinant antibody

  • Catalog No.:YA0222
  • Applications:FCM;ELISA
  • Reactivity:Human
    • Target:
    • CD269/BCMA
    • Gene Name:
    • TNFRSF17 BCM BCMA
    • Protein Name:
    • Tumor necrosis factor receptor superfamily member 17 (B-cell maturation protein) (CD antigen CD269)
    • Human Gene Id:
    • 608
    • Human Swiss Prot No:
    • Q02223
    • Immunogen:
    • Purified recombinant Human CD269
    • Specificity:
    • This recombinant monoclonal antibody can detects endogenous levels of CD269/BCMA protein.
    • Formulation:
    • Phosphate-buffered solution
    • Source:
    • Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
    • Dilution:
    • ELISA 1:5000-100000;FCM 1-2μg/Test
    • Purification:
    • Recombinant Expression and Affinity purified
    • Concentration:
    • Please check the information on the tube
    • Storage Stability:
    • -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
    • Other Name:
    • TNFRSF17;BCM;BCMA;Tumor necrosis factor receptor superfamily member 17;B-cell maturation protein;CD269;CD269 nanobody;BCMA nanobody;
    • Background:
    • The protein encoded byThis gene is a member of the TNF-receptor superfamily.This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response.This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation.This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]
    • Function:
    • disease:A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.,Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.,similarity:Contains 1 TNFR-Cys repeat.,subcellular location:Perinuclear Golgi-like structures.,subunit:Associates with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6.,tissue specificity:Expressed in mature B-cells, but not in T-cells or monocytes.,
    • Subcellular Location:
    • Cell membrane; Single-pass type III membrane protein. Endomembrane system; Single-pass type III membrane protein. Perinuclear Golgi-like structures.
    • Expression:
    • Expressed in mature B-cells, but not in T-cells or monocytes.