• Target：
• QIK/QSK

• Fields：
• >>Glucagon signaling pathway

• Gene Name：
• SIK1 SIK SNF1LK

• Protein Name：
• QIK/QSK

• Human Gene Id：
• 150094

• Human Swiss Prot No：
• P57059

• Mouse Gene Id：
• 17691

• Mouse Swiss Prot No：
• Q60670

• Rat Gene Id：
• 59329

• Rat Swiss Prot No：
• Q9R1U5

• Immunogen：
• Synthesized peptide derived from human QIK/QSK

• Specificity：
• This antibody detects endogenous levels of QIK/QSK at Human, Mouse,Rat

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• Serine/threonine-protein kinase SIK1 (EC 2.7.11.1) (Salt-inducible kinase 1) (SIK-1) (Serine/threonine-protein kinase SNF1-like kinase 1) (Serine/threonine-protein kinase SNF1LK)

• Molecular Weight(Da)：
• 86kD

• Function：
• catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-182 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39.,function:Transient role during the earliest stages of myocardial cell differentiation and/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and/or differentiation. Potential role in G2/M cell cycle regulation. Inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 UBA domain.,subcellular location:Translocates to the cytoplasm on phosp

• Subcellular Location：
• Cytoplasm . Nucleus . Locates to cytoplasm when inactive following cAMP-induced phosphorylation, probably by PKA (PubMed:29211348).

• Expression：
• Fetal lung,Spleen,Testis,

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