• Target：
• XRCC1

• Fields：
• >>Base excision repair

• Gene Name：
• XRCC1

• Protein Name：
• XRCC1 (Phospho-Thr284)

• Human Gene Id：
• 7515

• Human Swiss Prot No：
• P18887

• Mouse Gene Id：
• 22594

• Mouse Swiss Prot No：
• Q60596

• Rat Gene Id：
• 84495

• Rat Swiss Prot No：
• Q9ESZ0

• Immunogen：
• Synthesized peptide derived from human XRCC1 (Phospho-Thr284)

• Specificity：
• This antibody detects endogenous levels of XRCC1 (Phospho-Thr284) at Human, Mouse,Rat

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000

• Purification：
• The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1)

• Molecular Weight(Da)：
• 70kD

• Background：
• The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008],

• Function：
• function:Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.,polymorphism:Carriers of the polymorphic Gln-399 allele may be at greater risk for tobacco- and age-related DNA damage.,PTM:Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF.,PTM:Sumoylated.,similarity:Contains 2 BRCT domains.,subcellular location:Accumulates at sites of DNA damage.,subunit:Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF.,

• Subcellular Location：
• Nucleus . Moves from the nucleoli to the global nuclear chromatin upon DNA damage. .

• Expression：
• Expressed in fibroblasts, retinal pigmented epithelial cells and lymphoblastoid cells (at protein level).

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