• Target：
• RanBP3

• Fields：
• >>Human T-cell leukemia virus 1 infection

• Gene Name：
• RANBP3

• Protein Name：
• RanBP3 (Ser58)

• Human Gene Id：
• 8498

• Human Swiss Prot No：
• Q9H6Z4

• Mouse Gene Id：
• 71810

• Mouse Swiss Prot No：
• Q9CT10

• Immunogen：
• Synthesized phosho peptide around human RanBP3 (Ser58)

• Specificity：
• This antibody detects endogenous levels of Human RanBP3 (phospho-Ser58)

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• Purification：
• The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• Ran-binding protein 3 (RanBP3)

• Observed Band(KD)：
• 60kD

• Background：
• This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],

• Function：
• function:Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 RanBD1 domain.,subunit:Interacts with CHC1 in a Ran-stimulated manner. Interacts with XPO1.,tissue specificity:Widely expressed with high levels in testis and heart.,

• Subcellular Location：
• Cytoplasm . Nucleus .

• Expression：
• Widely expressed with high levels in testis and heart.

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