ZAP-70(PT2241) mouse mAb

    • Catalog No.:YM6657
    • Applications:IHC-p,WB
    • Reactivity:Human
    • Description
    • Gene Name:
    • ZAP70 SRK
    • Protein Name:
    • Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase)
    • Human Gene Id:
    • 7535
    • Human Swiss Prot No:
    • P43403
    • Immunogen:
    • Synthesized peptide derived from human ZAP-70
    • Specificity:
    • This antibody detects endogenous levels of human Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase)
    • Formulation:
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source:
    • Mouse/IgG1, Kappa
    • Dilution:
    • IHC-p 1:100-500,WB 1:500-2000
    • Purification:
    • The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
    • Concentration:
    • 1 mg/ml
    • Storage Stability:
    • -20°C/1 year
    • Background:
    • ZAP70 (zeta chain of T cell receptor associated protein kinase 70) encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in ZAP70 cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for ZAP70.
    • Function:
    • cell activation, activation of immune response, immune response-activating cell surface receptor signaling pathway,immune system development, leukocyte differentiation, positive regulation of immune system process, regulation of leukocyte activation, positive regulation of leukocyte activation, immune response-activating signal transduction,immune response-regulating signal transduction, immune response-regulating cell surface receptor signaling pathway,protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, immune response,cell surface receptor linked signal transduction, intracellular signaling cascade, protein kinase cascade, positive regulation of cell proliferation, positive regulation of signal transduction, positive regulation of cell communication,phosphorylation, peptidyl-tyrosine phosphorylation, peptidyl-tyrosine modification, hemopoiesis
    • Products Images
    • Immunohistochemical analysis of paraffin-embedded human Hodgkin's lymphoma. 1,ZAP-70 Antibody was diluted at 1:200(4°,overnight). 2, Citrate buffer of pH6.0 was used for antigen retrieval
    • Immunohistochemical analysis of paraffin-embedded human Tonsil. 1,ZAP-70 Antibody was diluted at 1:200(4°,overnight). 2, Citrate buffer of pH6.0 was used for antigen retrieval
    • Immunohistochemical analysis of paraffin-embedded human Tonsil. 1,ZAP-70 Antibody was diluted at 1:200(4°,overnight). 2, Citrate buffer of pH6.0 was used for antigen retrieval