β-actin Monoclonal Antibody(5B7), AbFluor™ 555 Conjugated
- Catalog No.:YM2188
- Applications:IF/ICC,WB,IHC-p
- Reactivity:Human,Rat,Mouse,Mk,Dg,Ch,Hamster,Rb,Insect
- Gene Name:
- ACTB
- Protein Name:
- Actin cytoplasmic 1
- Human Gene Id:
- 60
- Human Swiss Prot No:
- P60709
- Specificity:
- β-actin Monoclonal Antibody(5B7) AbFluor™ 555 Conjugated specially designed for your Immunofluorescence analysis.
- Formulation:
- Liquid in PBS, pH 7.4, containing 0.02% sodium azide as preservative and 50% Glycerol.
- Source:
- Monoclonal, Mouse IgG1
- Dilution:
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC: 1:200, IF 1:200.
- Purification:
- The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
- Concentration:
- 1mg/ml
- Storage Stability:
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and th
- Other Name:
- ACTB
- Background:
- actin beta(ACTB) Homo sapiens This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, and integrity. This actin is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins. [provided by RefSeq, Jul 2008],
- Function:
- disease:Defects in ACTB are a cause of dystonia juvenile-onset (DYTJ) [MIM:607371]. DYTJ is a form of dystonia with juvenile onset. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. DYTJ patients manifest progressive, generalized, dopa-unresponsive dystonia, developmental malformations and sensory hearing loss.,function:Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.,miscellaneous:In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.,similarity:Belongs to the
- Subcellular Location:
- Cytoplasm, cytoskeleton . Nucleus . Localized in cytoplasmic mRNP granules containing untranslated mRNAs. .
- Expression:
- B-cell lymphoma,Brain,Cajal-Retzius cell,Eye,Fetal brain cortex,Foreskin,Hepatocellular car
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