CZ415

    • Catalog No.:MC1383
    • Description
    • CasNo:
    • 1429639-50-8
    • MolecularFormula:
    • C22H29N5O4S
    • Purity:
    • >98%
    • Target:
    • mTOR
    • IC50:
    • mTOR[1]IC50: 14.5 nM (pS6RP), 14.8 nM (pAKT), 226 nM (IFNγ)[1]
    • In Vitro:
    • Inhibition of phosphorylation for both downstream targets results in 14.5 nM IC50 for pS6RP and 14.8
    • In Vivo:
    • CZ415 is a highly selective mTOR inhibitor showing in vivo efficacy in a collagen induced arthritis
    • Fields:
    • CZ415 is a potent and highly selective mTOR inhibitor. mTOR[1]IC50: 14.5 nM (pS6RP), 14.8 nM (pAKT),
    • Specificity:
    • Target: mTOR. Fields: CZ415 is a potent and highly selective mTOR inhibitor. mTOR[1]IC50: 14.5 nM (pS6RP), 14.8 nM (pAKT), 226 nM (IFNγ)[1]
    • Dilution:
    • mTOR[1]IC50: 14.5 nM (pS6RP), 14.8 nM (pAKT), 226 nM (IFNγ)[1]
    • Concentration:
    • >98%
    • Storage Stability:
    • 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
    • Other Name:
    • CZ-415; CZ 415
    • MolecularWeight(Da):
    • 459.56
    • References:
    • [1]. Cansfield AD, et al. CZ415, a Highly Selective mTOR Inhibitor Showing in Vivo Efficacy in a Collagen Induced Arthritis Model. ACS Med Chem Lett. 2016 Jun 10;7(8):768-73.
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