Total SEK1/MKK4 Cell-Based Colorimetric ELISA Kit
- Catalog No.:KA4273C
- Applications:ELISA
- Reactivity:Human;Mouse;Rat
- Gene Name:
- MAP2K4
- Human Gene Id:
- 6416
- Human Swiss Prot No:
- P45985
- Mouse Swiss Prot No:
- P47809
- Storage Stability:
- 2-8°C/6 months
- Other Name:
- Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1) (Stress-activated protein kinase kinase 1) (SAPK kinase 1) (SAPKK-1) (SAPKK1) (c-Jun N-terminal kinase kinase 1) (JNKK)
- Detection Method:
- Colorimetric
- Background:
- catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Dual specificity kinase that activates the JUN kinases MAPK8 (JNK1) and MAPK9 (JNK2) as well as MAPK14 (p38) but not MAPK1 (ERK2) or MAPK3 (ERK1).,PTM:Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with SPAG9.,tissue specificity:Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.,
- Function:
- MAPKKK cascade, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process,intracellular signaling cascade, protein kinase cascade, JNK cascade, phosphorylation, stress-activated protein kinase signaling pathway, cellular response to stress,
- Subcellular Location:
- Cytoplasm . Nucleus .
- Expression:
- Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.
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