Total ACCα Cell-Based Colorimetric ELISA Kit

  • Catalog No.：KA3003C
  • Applications：ELISA
  • Reactivity：Human;Mouse;Rat
    • Gene Name：
    • ACACA
    • Human Gene Id：
    • 31
    • Human Swiss Prot No：
    • Q13085
    • Mouse Swiss Prot No：
    • Q5SWU9
    • Storage Stability：
    • 2-8°C/6 months
    • Other Name：
    • Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (ACC-alpha) [Includes: Biotin carboxylase (EC 6.3.4.14)]
    • Detection Method：
    • Colorimetric
    • Background：
    • catalytic activity:ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA.,catalytic activity:ATP + biotin-carboxyl-carrier protein + CO(2) = ADP + phosphate + carboxybiotin-carboxyl-carrier protein.,cofactor:Binds 2 manganese ions per subunit.,cofactor:Biotin.,disease:Defects in ACACA are a cause of ACACA deficiency [MIM:200350]; also called ACAC or ACC deficiency. ACACA deficiency is an inborn error of de novo fatty acid synthesis. The disorder is associated with severe brain damage, persistent myopathy and poor growth.,enzyme regulation:By phosphorylation.,function:Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.,online information:Acetyl-CoA carboxylase entry,pathway:Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.,PTM:Phosphorylation on Ser-1263 is required for interaction with BRCA1.,similarity:Contains 1 ATP-grasp domain.,similarity:Contains 1 biotin carboxylation domain.,similarity:Contains 1 biotinyl-binding domain.,similarity:Contains 1 carboxyltransferase domain.,subunit:Interacts in its inactive phosphorylated form with the BRCT domains of BRCA1 which prevents ACACA dephosphorylation and inhibits lipid synthesis.,tissue specificity:Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver.,
    • Function：
    • tissue homeostasis, acetyl-CoA metabolic process, fatty acid metabolic process, fatty acid biosynthetic process,coenzyme metabolic process, lipid biosynthetic process, response to organic substance, response to organic cyclic substance, organic acid biosynthetic process, response to drug, homeostatic process, multicellular organismal metabolic process, multicellular organismal macromolecule metabolic process, multicellular organismal protein metabolic process, carboxylic acid biosynthetic process, multicellular organismal homeostasis, chemical homeostasis,cofactor metabolic process, lipid homeostasis, anatomical structure homeostasis,
    • Subcellular Location：
    • Cytoplasm, cytosol .
    • Expression：
    • Expressed in brain, placenta, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver.

    Attributes

    • Code：
    • KA3003C
    • Size
    • 96 / well
    • Price$：
    • 330
    • Delivery：
    • 2024-12-11
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