Phospho-PYK2 (Y881) Cell-Based Colorimetric ELISA Kit

  • Catalog No.:KA1217C
  • Applications:ELISA
  • Reactivity:Human,Mouse,Rat
    • Gene Name:
    • PTK2B
    • Human Gene Id:
    • 2185
    • Human Swiss Prot No:
    • Q14289
    • Mouse Swiss Prot No:
    • Q9QVP9
    • Storage Stability:
    • 4°C/6 months
    • Other Name:
    • Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK)
    • Detection Method:
    • Colorimetric
    • Background:
    • catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. May represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA 'Tyr-125' phosphorylation.,PTM:Phosphorylated on tyrosine residues in response to various stimuli that elevate the intracellular calcium concentration, as well as by PKC activation. Recruitment by nephrocystin to cell matrix adhesions initiates Tyr-402 phosphorylation. In monocytes, adherence to substrata is required for tyrosine phosphorylation and kinase activation. Angiotensin II, thapsigargin and L-alpha-lysophosphatidic acid (LPA) also induce autophosphorylation and increase kinase activity.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily.,similarity:Contains 1 FERM domain.,similarity:Contains 1 protein kinase domain.,subcellular location:Interaction with nephrocystin induces the membrane-association of the kinase.,subunit:Interacts with Crk-associated substrate (Cas), PTPNS1 and SH2D3C (By similarity). Interacts with nephrocystin, ASAP2, OPHN1L, SKAP2 and TGFB1I1.,tissue specificity:Most abundant in the brain, with highest levels in amygdala and hippocampus. Low levels in kidney. Also expressed in spleen and lymphocytes.,
    • Function:
    • MAPKKK cascade, response to reactive oxygen species, angiogenesis, oocyte maturation, regulation of cell growth,blood vessel development, response to hypoxia, regulation of protein amino acid phosphorylation, vasculature development, reproductive developmental process, regulation of translation, protein complex assembly, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, oxygen and reactive oxygen species metabolic process, cellular ion homeostasis, cellular calcium ion homeostasis, cellular metal ion homeostasis,apoptosis, cell motion, response to osmotic stress, response to oxidative stress, cytoskeleton organization, actin filament organization, cell-substrate junction assembly, cell adhesion, cell-matrix adhesion, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor prote