• Gene Name：
• PLCG2

• Human Gene Id：
• 5336

• Human Swiss Prot No：
• P16885

• Mouse Swiss Prot No：
• Q8CIH5

• Rat Swiss Prot No：
• P24135

• Storage Stability：
• 2-8°C/6 months

• Other Name：
• 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2)

• Detection Method：
• Colorimetric

• Background：
• catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.,cofactor:Calcium.,function:The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.,PTM:Phosphorylated on tyrosine residues; upon ligand-induced activation of a variety of growth factor receptors and immune system receptors. Increases phospholipase activity.,similarity:Contains 1 C2 domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 PI-PLC X-box domain.,similarity:Contains 1 PI-PLC Y-box domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 SH2 domains.,

• Function：
• cell activation, response to molecule of bacterial origin, activation of immune response, cell activation during immune response, lymphocyte activation during immune response, B cell activation during immune response, mature B cell differentiation during immune response, follicular B cell differentiation, mature B cell differentiation, leukocyte activation during immune response, immune response-activating cell surface receptor signaling pathway, immune system development, leukocyte differentiation, positive regulation of immune system process, immune response-activating signal transduction, immune response-regulating signal transduction, immune response-regulating cell surface receptor signaling pathway, inositol metabolic process, inositol biosynthetic process, phospholipid metabolic process, cellular ion homeostasis, cellular calcium ion homeostasis, cellular metal ion homeostasis, im

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