- 靶点：
- TXNIP
- 基因名称：
- TXNIP VDUP1
- 蛋白名称：
- Thioredoxin-interacting protein (Thioredoxin-binding protein 2) (Vitamin D3 up-regulated protein 1)
- Human Gene Id：
- 10628
- Human Swiss Prot No：
- Q9H3M7
- Mouse Gene Id：
- 56338
- Mouse Swiss Prot No：
- Q8BG60
- Rat Gene Id：
- 117514
- Rat Swiss Prot No：
- Q5M7W1
- 免疫原：
- Synthesized peptide derived from human N-ternal TXNIP
- 特异性：
- This antibody detects endogenous levels of TXNIP at Human, Mouse,Rat
- 组成：
- Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500-2000 IHC 1:50-200
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 浓度：
- 1 mg/ml
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- Thioredoxin-interacting protein (Thioredoxin-binding protein 2) (Vitamin D3 up-regulated protein 1)
- 分子量：
- 43kD
- 功能：
- May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).
- 细胞定位：
- Cytoplasm .
Sinensetin, a polymethoxyflavone from citrus fruits, ameliorates LPS-induced acute lung injury by suppressing Txnip/NLRP3/Caspase-1/GSDMD signaling-mediated inflammatory responses and pyroptosis Food & Function Zaibin Xu WB Mouse lung tissue RAW264.7 cell
货号：YT8122
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