• 靶点：
• MCM10

• 基因名称：
• MCM10 PRO2249

• 蛋白名称：
• Protein MCM10 homolog (HsMCM10)

• Human Gene Id：
• 55388

• Human Swiss Prot No：
• Q7L590

• Mouse Gene Id：
• 70024

• Mouse Swiss Prot No：
• Q0VBD2

• 免疫原：
• Synthesized peptide derived from human N-ternal MCM10

• 特异性：
• This antibody detects endogenous levels of MCM10 at Human, Mouse

• 组成：
• Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000 IHC 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Protein MCM10 homolog (HsMCM10)

• 分子量：
• 96kD

• 功能：
• Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 .

• 细胞定位：
• Nucleus . Colocalizes with ORC2 in nuclei foci. Associated with chromatin in S phase. From early to mid-S phase located in discrete nuclear foci. In early S phase, several hundred foci appeared throughout the nucleus. In mid-S phase, the foci appeared at the nuclear periphery and nucleolar regions. In the late S and G phases localized to nucleoli.

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