LOX12 rabbit pAb

  • 货号：YT8083
  • 应用：IHC;WB
  • 种属：Human;Mouse
    • 靶点：
    • ALOX12
    • 基因名称：
    • ALOX12 LOG12
    • 蛋白名称：
    • Arachidonate 12-lipoxygenase, 12S-type (12S-LOX) (12S-lipoxygenase) (EC 1.13.11.31) (Platelet-type lipoxygenase 12)
    • Human Gene Id：
    • 239
    • Human Swiss Prot No：
    • P18054
    • Mouse Swiss Prot No：
    • P39655
    • 免疫原：
    • Synthesized peptide derived from human N-ternal LOX12
    • 特异性：
    • This antibody detects endogenous levels of LOX12 at Human, Mouse
    • 组成：
    • Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
    • 来源：
    • Polyclonal, Rabbit,IgG
    • 稀释：
    • WB 1:500-2000 IHC 1:50-200
    • 纯化工艺：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • 浓度：
    • 1 mg/ml
    • 储存：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • 其他名称：
    • Arachidonate 12-lipoxygenase, 12S-type (12S-LOX) (12S-lipoxygenase) (EC 1.13.11.31) (Platelet-type lipoxygenase 12)
    • 分子量：
    • 73kD
    • 功能：
    • Catalyzes the regio and stereo-specific incorporation of molecular oxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species . Mainly converts arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) to the specific bioactive lipid (12S)-hydroperoxyeicosatetraenoate/(12S)-HPETE . Through the production of bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation . It can also catalyze the epoxidation of double bonds of polyunsaturated fatty acids such as (14S)-hydroperoxy-docosahexaenoate/(14S)-HPDHA resulting in the formation of (13S,14S)-epoxy-DHA . Furthermore, it may participate in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs) like resolvin D5 ((7S,17S)-diHPDHA
    • 细胞定位：
    • Cytoplasm, cytosol. Membrane. Membrane association is stimulated by EGF.
    • 组织表达：
    • Expressed in vascular smooth muscle cells.

    相关报价

    • 货号：
    • YT8083
    • 规格：
    • 40μL / 100μL / 200μL
    • 价格：
    • ¥960 / 2300 / 3780
    • 货期：
    • 预计发货时间为
      2024-07-25
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