• 靶点：
• VR1

• 简介：
• >>Neuroactive ligand-receptor interaction;>>Inflammatory mediator regulation of TRP channels

• 基因名称：
• TRPV1 VR1

• 蛋白名称：
• VR1

• Human Gene Id：
• 7442

• Human Swiss Prot No：
• Q8NER1

• Mouse Gene Id：
• 193034

• Mouse Swiss Prot No：
• Q704Y3

• Rat Gene Id：
• 83810

• Rat Swiss Prot No：
• O35433

• 免疫原：
• Synthesized peptide derived from human VR1

• 特异性：
• This antibody detects endogenous levels of VR1 at Human, Mouse,Rat

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Transient receptor potential cation channel subfamily V member 1 (TrpV1) (Capsaicin receptor) (Osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1)

• 分子量：
• 92kD

• 背景：
• transient receptor potential cation channel subfamily V member 1(TRPV1) Homo sapiens Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008],

• 功能：
• domain:The association domain (AD) is necessary for self-association.,enzyme regulation:Channel activity is activated via the interaction with PIRT and phosphatidylinositol-4,5-bisphosphate (PIP2). Both PIRT and PIP2 are required to activate channel activity.,function:Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL.,miscellaneous:Responses evoked by low pH and heat, and capsaicin can be antagonized by capsazepine.,PTM:Phosphorylation by PKA reverses capsaicin-induced dephosphorylation at multiple sites, proba

• 细胞定位：
• Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cell projection, dendritic spine membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Mostly, but not exclusively expressed in postsynaptic dendritic spines. .

• 组织表达：
• Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands (at protein level).

Ambient NO2 exposure induces migraine in rats: Evidence, mechanisms and interventions WB Rat /trigeminal nerve cells
货号：YT7995

Role of TRPA1/TRPV1 in acute ozone exposure induced murine model of airway inflammation and bronchial hyperresponsiveness Journal of Thoracic Disease Feng Li WB Mouse
货号：YT7995

Accelerated osteogenesis of bone graft by optimizing the bone microenvironment formed by electrical signals dependent on driving micro vibration stimulation Materials Today Bio Yuehao Wu WB Mouse 1:500 MC3T3-E1 cell
货号：YT7995

Mechanism of NO2-induced migraine in rats: The exploration of the role of miR-653-3p/IGF1 axis JOURNAL OF HAZARDOUS MATERIALS Shuzi Ye WB Rat 1:1000 trigeminal ganglion primary trigeminal ganglion neurons (PTGNs)
货号：YT7995

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