- 靶点：
- BMP-4
- 简介：
- >>Cytokine-cytokine receptor interaction;>>TGF-beta signaling pathway;>>Hippo signaling pathway;>>Signaling pathways regulating pluripotency of stem cells;>>Thyroid hormone signaling pathway;>>Pathways in cancer;>>Basal cell carcinoma;>>Fluid shear stress and atherosclerosis
- 基因名称：
- BMP4 BMP2B DVR4
- 蛋白名称：
- BMP-4
- Human Gene Id：
- 652
- Human Swiss Prot No：
- P12644
- Mouse Gene Id：
- 12159
- Mouse Swiss Prot No：
- P21275
- Rat Swiss Prot No：
- Q06826
- 免疫原：
- Synthesized peptide derived from human BMP-4 AA range: 261-310
- 特异性：
- This antibody detects endogenous levels of Human BMP-4
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:1000-2000 ELISA 1:5000-20000
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 浓度：
- 1 mg/ml
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- Bone morphogenetic protein 4 (BMP-4;Bone morphogenetic protein 2B;BMP-2B)
- 分子量：
- 45kD
- 背景：
- disease:Defects in BMP4 are the cause of microphthalmia syndromic type 6 (MCOPS6) [MIM:607932]; also known as microphthalmia and pituitary anomalies or microphthalmia with brain and digit developmental anomalies. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS6 is characterized by microphthalmia/anophthalmia associated with facial, genital, skeletal, neurologic and endocrine anomalies.,function:Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair.,online information:Bone morphogenetic protein 4 entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked (By similarity). Interacts with GREM2 (By similarity) and SOSTDC1. Part of a complex consisting of TWSG1 and CHRD.,tissue specificity:Expressed in the lung and lower levels seen in the kidney. Present also in normal and neoplastic prostate tissues, and prostate cancer cell lines.,
- 功能：
- skeletal system development, ossification, angiogenesis, ovarian follicle development, blood vessel development,osteoblast differentiation, eye development, urogenital system development, metanephros development, ureteric bud development, branching involved in ureteric bud morphogenesis, formation of primary germ layer, mesoderm formation, cell fate specification, cell fate determination, mesodermal cell fate commitment, induction of an organ,morphogenesis of a branching structure, kidney development, regulation of protein amino acid phosphorylation,positive regulation of protein amino acid phosphorylation, vasculature development, morphogenesis of an epithelium,lens development in camera-type eye, lens morphogenesis in camera-type eye, immune system development,regionalization, reproductive developmental process, regulation of transcription, DNA-dependent, regulation of transcription fr
- 细胞定位：
- Secreted, extracellular space, extracellular matrix.
- 组织表达：
- Expressed in the lung and lower levels seen in the kidney. Present also in normal and neoplastic prostate tissues, and prostate cancer cell lines.
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