VCAM-1 rabbit pAb

  • 货号：YT7839
  • 应用：WB;ELISA
  • 种属：Human;Rat;Mouse;
    • 靶点：
    • VCAM-1
    • 简介：
    • >>NF-kappa B signaling pathway;>>Cell adhesion molecules;>>TNF signaling pathway;>>Leukocyte transendothelial migration;>>AGE-RAGE signaling pathway in diabetic complications;>>African trypanosomiasis;>>Malaria;>>Lipid and atherosclerosis;>>Fluid shear stress and atherosclerosis
    • 基因名称：
    • VCAM1 L1CAM
    • 蛋白名称：
    • VCAM-1
    • Human Gene Id：
    • 7412
    • Human Swiss Prot No：
    • P19320
    • Mouse Swiss Prot No：
    • P29533
    • 免疫原：
    • Synthesized peptide derived from human VCAM-1 AA range: 551-600
    • 特异性：
    • This antibody detects endogenous levels of Human VCAM-1
    • 组成：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • 来源：
    • Polyclonal, Rabbit,IgG
    • 稀释：
    • WB 1:1000-2000 ELISA 1:5000-20000
    • 纯化工艺：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • 浓度：
    • 1 mg/ml
    • 储存：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • 其他名称：
    • Vascular cell adhesion protein 1 (V-CAM 1;VCAM-1;INCAM-100;CD antigen CD106)
    • 分子量：
    • 81kD
    • 背景：
    • This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010],
    • 功能：
    • alternative products:Additional isoforms seem to exist,disease:May play an important role in the genesis of atherosclerosis and rheumatoid arthritis.,domain:Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.,function:Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.,induction:By cytokines (e.g. IL-1, TNF-alpha).,online information:VCAM-1,online information:VCAM1 entry,PTM:Sialoglycoprotein.,similarity:Contains 7 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Binds to ECMV-D capsid proteins and acts as a receptor for this virus.,tissue specificit
    • 细胞定位：
    • Membrane; Single-pass type I membrane protein.
    • 组织表达：
    • Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue.

    CLIC1 Inhibition Attenuates Vascular Inflammation, Oxidative Stress, and Endothelial Injury. PLoS One Plos One. 2016 Nov;11(11):e0166790 WB Human,Mouse aortas HUVECs
    货号：YT7839

    Tanshinone IIA Sodium sulfonate regulates antioxidant system, inflammation, and endothelial dysfunction in atherosclerosis by downregulation of CLIC1. EUROPEAN JOURNAL OF PHARMACOLOGY Eur J Pharmacol. 2017 Nov;815:427 WB Mouse,Human aortas HUVECs
    货号：YT7839

    相关报价

    • 货号：
    • YT7839
    • 规格：
    • 40μL / 100μL / 200μL
    • 价格：
    • ¥960 / 2300 / 3780
    • 货期：
    • 预计发货时间为
      2024-11-23
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