• 靶点：
• MTMRC

• 基因名称：
• MTMR12 KIAA1682 PIP3AP

• 蛋白名称：
• MTMRC

• Human Gene Id：
• 54545

• Human Swiss Prot No：
• Q9C0I1

• Mouse Gene Id：
• 268783

• Mouse Swiss Prot No：
• Q80TA6

• Rat Gene Id：
• 310155

• Rat Swiss Prot No：
• Q5FVM6

• 免疫原：
• Synthesized peptide derived from human MTMRC AA range: 523-573

• 特异性：
• This antibody detects endogenous levels of MTMRC at Human/Mouse/Rat

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 82kD

• 背景：
• Phosphatidylinositide 3-kinase-derived membrane-anchored phosphatidylinositides, such as phosphatidylinositol 3-phosphate (PtdIns(3)P), regulate diverse cellular processes. The protein encoded by this gene functions as an adaptor subunit in a complex with an active PtdIns(3)P 3-phosphatase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014],

• 功能：
• caution:Lacks the phosphocysteine intermediate Cys active site in position 391 that is replaced by a Glu residue, preventing the hydrolase activity.,function:Inactive phosphatase that plays a role as an adapter for the phosphatase myotubularin to regulate myotubularin intracellular location.,miscellaneous:Catalytically inactive phosphatase.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.,similarity:Contains 1 myotubularin phosphatase domain.,subcellular location:Localizes to punctate vesicles when associated with MTM1.,subunit:Interacts with myotubularin MTM1 and myotubularin-related MTMR2.,tissue specificity:Ubiquitous with prominent expression in brain, heart, kidney, placenta, and lung.,

• 细胞定位：
• Cytoplasm . Sarcoplasmic reticulum . Cytoplasm, myofibril, sarcomere . Localizes to punctate vesicles when associated with MTM1 (PubMed:12847286). Localizes to triads, a structure formed by a T tubule and two sarcoplasmic reticulum terminal cisterna (By similarity). In skeletal muscles, co-localizes with MTM1 in the sarcomere (By similarity). Partially localizes to the sarcoplasmic reticulum in skeletal muscles (By similarity). .

• 组织表达：
• Expressed in skeletal muscles (at protein level) (PubMed:23818870). Ubiquitous with prominent expression in brain, heart, kidney, placenta, and lung (PubMed:11504939).

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