• 靶点：
• QCR1

• 简介：
• >>Oxidative phosphorylation;>>Metabolic pathways;>>Cardiac muscle contraction;>>Thermogenesis;>>Non-alcoholic fatty liver disease;>>Alzheimer disease;>>Parkinson disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Chemical carcinogenesis - reactive oxygen species;>>Diabetic cardiomyopathy

• 基因名称：
• UQCRC1

• 蛋白名称：
• QCR1

• Human Gene Id：
• 7384

• Human Swiss Prot No：
• P31930

• Mouse Gene Id：
• 22273

• Mouse Swiss Prot No：
• Q9CZ13

• Rat Gene Id：
• 301011

• Rat Swiss Prot No：
• Q68FY0

• 免疫原：
• Synthesized peptide derived from human QCR1 AA range: 164-214

• 特异性：
• This antibody detects endogenous levels of QCR1 at Human/Mouse/Rat

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 53kD

• 功能：
• caution:Does not seem to have a protease activity as it lack the zinc-binding site.,function:This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.,similarity:Belongs to the peptidase M16 family. UQCRC1/QCR1 subfamily.,subunit:The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).,

• 细胞定位：
• Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side .

• 组织表达：
• Expressed in brain, including substantia nigra, striatum, cortex and cerebellum, and in spinal cord, heart, kidney, liver and muscle.

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