• 靶点：
• FAN1

• 简介：
• >>Fanconi anemia pathway

• 基因名称：
• FAN1 KIAA1018 MTMR15

• 蛋白名称：
• FAN1

• Human Gene Id：
• 22909

• Human Swiss Prot No：
• Q9Y2M0

• Mouse Gene Id：
• 330554

• Mouse Swiss Prot No：
• Q69ZT1

• 免疫原：
• Synthesized peptide derived from human FAN1 AA range: 801-851

• 特异性：
• This antibody detects endogenous levels of FAN1 at Human/Mouse

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1：500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 112kD

• 背景：
• This gene plays a role in DNA interstrand cross-link repair and encodes a protein with 5' flap endonuclease and 5'-3' exonuclease activity. Mutations in this gene cause karyomegalic interstitial nephritis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Feb 2016],

• 功能：
• similarity:Belongs to the MTMR15 family.,

• 细胞定位：
• Nucleus . Localizes at sites of DNA damage following recruitment by monoubiquitinated FANCD2 (PubMed:20603015, PubMed:20603016). Localizes to stalled replication forks via its UBZ4-type zinc finger (PubMed:20935496). .

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