• 靶点：
• ABR

• 基因名称：
• ABR

• 蛋白名称：
• ABR

• Human Gene Id：
• 29

• Human Swiss Prot No：
• Q12979

• Mouse Gene Id：
• 109934

• Mouse Swiss Prot No：
• Q5SSL4

• 免疫原：
• Synthesized peptide derived from human ABR AA range: 393-443

• 特异性：
• This antibody detects endogenous levels of ABR at Human/Mouse

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1：500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 94kD

• 背景：
• This gene encodes a protein that is similar to the protein encoded by the breakpoint cluster region gene located on chromosome 22. The protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the Rho family of GTP-binding proteins. Functional studies in mice determined that this protein plays a role in vestibular morphogenesis. Alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Feb 2012],

• 功能：
• function:GTPase-activating protein for RAC and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them.,similarity:Contains 1 C2 domain.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 Rho-GAP domain.,tissue specificity:Highly enriched in the brain. Much weaker expression in heart, lung and muscle.,

• 细胞定位：
• Cell projection, dendritic spine . Cell projection, axon . Cell junction, synapse .

• 组织表达：
• Highly enriched in the brain. Much weaker expression in heart, lung and muscle.

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