• 靶点：
• NAL12

• 简介：
• >>NOD-like receptor signaling pathway

• 基因名称：
• NLRP12 NALP12 PYPAF7 RNO

• 蛋白名称：
• NAL12

• Human Gene Id：
• 91662

• Human Swiss Prot No：
• P59046

• Mouse Gene Id：
• 378425

• Mouse Swiss Prot No：
• E9Q5R7

• 免疫原：
• Synthesized peptide derived from human NAL12 AA range: 456-506

• 特异性：
• This antibody detects endogenous levels of NAL12 at Human/Mouse

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 117kD

• 背景：
• This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Mutations in this gene cause familial cold autoinflammatory syndrome type 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013],

• 功能：
• disease:Defects in NLRP12 are the cause of familial cold autoinflammatory syndrome type 2 (FCAS2) [MIM:611762]. FCAS are rare autosomal dominant systemic inflammatory diseases characterized by episodes of rash, arthralgia, fever and conjunctivitis after generalized exposure to cold.,function:May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.,induction:By nitric oxide and DMSO in HL60 cells, an acute myeloid leukemia cell line.,similarity:Belongs to the NLRP family.,similarity:Contains 1 DAPIN domain.,similarity:Contains 1 NACHT domain.,similarity:Contains 8 LRR (leucine-rich) repeats.,subunit:Binds to ASC with its DAPIN domain.,tissue specificity:Detected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes.,

• 细胞定位：
• Cytoplasm .

• 组织表达：
• Detected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes.

Overexpression of NLRP12 enhances antiviral immunity and alleviates herpes simplex keratitis via pyroptosis/IL-18/IFN-γ signaling INTERNATIONAL IMMUNOPHARMACOLOGY Jiaxuan Jiang WB,IHC Mouse,Human eyeball tissue HCE-T cell
货号：YT7568

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