• 靶点：
• ACTY

• 简介：
• >>Amyotrophic lateral sclerosis;>>Huntington disease;>>Pathways of neurodegeneration - multiple diseases;>>Salmonella infection

• 基因名称：
• ACTR1B CTRN2

• 蛋白名称：
• ACTY

• Human Gene Id：
• 10120

• Human Swiss Prot No：
• P42025

• Mouse Gene Id：
• 226977

• Mouse Swiss Prot No：
• Q8R5C5

• 免疫原：
• Synthesized peptide derived from human ACTY AA range: 29-79

• 特异性：
• This antibody detects endogenous levels of ACTY at Human/Mouse

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1：500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 41kD

• 背景：
• This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins, which are of equal length and share 90% amino acid identity, are present in a constant ratio of approximately 1:15 in the dynactin complex. [provided by RefSeq, Aug 2008],

• 功能：
• function:Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.,similarity:Belongs to the actin family.,similarity:Belongs to the actin family. ARP1 subfamily.,

• 细胞定位：
• Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

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