• 靶点：
• SPP2A

• 基因名称：
• SPPL2A IMP3 PSL2 PSEC0147

• 蛋白名称：
• SPP2A

• Human Gene Id：
• 84888

• Human Swiss Prot No：
• Q8TCT8

• Mouse Gene Id：
• 66552

• Mouse Swiss Prot No：
• Q9JJF9

• 免疫原：
• Synthesized peptide derived from human SPP2A AA range: 66-116

• 特异性：
• This antibody detects endogenous levels of SPP2A at Human/Mouse

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 57kD

• 背景：
• This gene encodes a member of the GXGD family of aspartic proteases, which are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions, as well as a member of the signal peptide peptidase-like protease (SPPL) family. This protein is expressed in all major adult human tissues and localizes to late endosomal compartments and lysosomal membranes. A pseudogene of this gene also lies on chromosome 15. [provided by RefSeq, Feb 2012],

• 功能：
• function:Functions as an intramembrane protease. Functions in ITM2B processing.,similarity:Belongs to the peptidase A22B family.,similarity:Contains 1 PA (protease associated) domain.,subunit:Interacts with ITM2B.,

• 细胞定位：
• Late endosome membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein . Membrane ; Multi-pass membrane protein ; Lumenal side . Colocalizes with palmitoylated and myristoylated proteins at the plasma membrane.

• 组织表达：
• Ubiquitous.

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