• 靶点：
• N4BP2

• 基因名称：
• N4BP2 B3BP KIAA1413

• 蛋白名称：
• N4BP2

• Human Gene Id：
• 55728

• Human Swiss Prot No：
• Q86UW6

• 免疫原：
• Synthesized peptide derived from human N4BP2 AA range: 256-306

• 特异性：
• This antibody detects endogenous levels of N4BP2 at Human

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 195kD

• 背景：
• This gene encodes a protein containing a polynucleotide kinase domain (PNK) near the N-terminal region, and a Small MutS Related (Smr) domain near the C-terminal region. The encoded protein can bind to both B-cell leukemia/lymphoma 3 (BCL-3) and neural precursor cell expressed, developmentally downregulated 4, (Nedd4) proteins. This protein binds and hydrolyzes ATP, may function as a 5'-polynucleotide kinase, and has the capacity to be a ubiquitylation substrate. This protein may play a role in transcription-coupled DNA repair or genetic recombination. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016],

• 功能：
• domain:The Smr domain has nicking endonuclease activity, but no significant double strand cleavage or exonuclease activity.,function:Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination.,PTM:Ubiquitinated; this targets the protein for degradation by the proteasome.,similarity:Contains 1 CUE domain.,similarity:Contains 1 Smr domain.,subunit:Binds NEDD4 (By similarity). Binds BCL3 and CREBBP.,

• 细胞定位：
• Cytoplasm .

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