P4HA1 rabbit pAb

    • 货号：YT7464
    • 应用：WB
    • 种属：Human;Mouse;Rat
      • 靶点：
      • P4HA1
      • 简介：
      • >>Arginine and proline metabolism;>>Metabolic pathways
      • 基因名称：
      • P4HA1 P4HA
      • 蛋白名称：
      • P4HA1
      • Human Gene Id：
      • 5033
      • Human Swiss Prot No：
      • P13674
      • Mouse Swiss Prot No：
      • Q60715
      • 免疫原：
      • Synthesized peptide derived from human P4HA1 AA range: 461-511
      • 特异性：
      • This antibody detects endogenous levels of P4HA1 at Human/Mouse/Rat
      • 组成：
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • 来源：
      • Polyclonal, Rabbit,IgG
      • 稀释：
      • WB 1：500-2000
      • 纯化工艺：
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • 浓度：
      • 1 mg/ml
      • 储存：
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • 分子量：
      • 59kD
      • 背景：
      • This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008],
      • 功能：
      • catalytic activity:Procollagen L-proline + 2-oxoglutarate + O(2) = procollagen trans-4-hydroxy-L-proline + succinate + CO(2).,cofactor:Ascorbate.,cofactor:Binds 1 Fe(2+) ion per subunit.,function:Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.,similarity:Belongs to the P4HA family.,similarity:Contains 1 PKHD (prolyl/lysyl hydroxylase) domain.,similarity:Contains 1 TPR repeat.,subunit:Heterotetramer of two alpha-1 chains and two beta chains (the beta chain is the multi-functional PDI).,
      • 细胞定位：
      • Endoplasmic reticulum lumen.
      • 组织表达：
      • Expressed in the heart, liver, skeletal muscle, kidney, placenta, lung and pancreas.
      • 产品图片
      • Western blot analysis of lysates from VEC cells, primary antibody was diluted at 1:1000, 4°over night

      相关报价

      • 货号：
      • YT7464
      • 规格：
      • 40μL / 100μL / 200μL
      • 价格：
      • ¥960 / 2300 / 3780
      • 货期：
      • 预计发货时间为
        2024-09-02
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