• 靶点：
• PP12C

• 简介：
• >>Vascular smooth muscle contraction;>>Focal adhesion;>>Regulation of actin cytoskeleton;>>Oxytocin signaling pathway;>>Proteoglycans in cancer

• 基因名称：
• PPP1R12C LENG3 MBS85

• 蛋白名称：
• PP12C

• Human Gene Id：
• 54776

• Human Swiss Prot No：
• Q9BZL4

• Mouse Gene Id：
• 232807

• Mouse Swiss Prot No：
• Q3UMT1

• 免疫原：
• Synthesized peptide derived from human PP12C AA range: 542-592

• 特异性：
• This antibody detects endogenous levels of PP12C at Human/Mouse

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 86kD

• 背景：
• The gene encodes a subunit of myosin phosphatase. The encoded protein regulates the catalytic activity of protein phosphatase 1 delta and assembly of the actin cytoskeleton. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012],

• 功能：
• caution:Although assigned as two separate genes (PPP1R12C and LENG3), it is probable that LENG3 does not exist by itself and is a part of the PPP1R12C gene.,function:Regulates myosin phosphatase activity.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Unspliced mRNA.,similarity:Contains 4 ANK repeats.,subcellular location:Along actomyosin filaments and stress fibers.,subunit:PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, and one or several targeting or regulatory subunits. PPP1R12C mediates binding to myosin. Interacts via its N-terminus with PPP1CB. Interacts with IL16. Interacts with the coiled-coil domain of MPRIP.,tissue specificity:Ubiquitously expressed. Highly expressed in heart.,

• 细胞定位：
• Cytoplasm . Cytoplasm, cytoskeleton, stress fiber .

• 组织表达：
• Ubiquitously expressed. Highly expressed in heart.

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