• 靶点：
• FBX22

• 简介：
• >>Salmonella infection

• 基因名称：
• FBXO22 FBX22

• 蛋白名称：
• FBX22

• Human Gene Id：
• 26263

• Human Swiss Prot No：
• Q8NEZ5

• Mouse Gene Id：
• 71999

• Mouse Swiss Prot No：
• Q78JE5

• 免疫原：
• Synthesized peptide derived from human FBX22 AA range: 182-232

• 特异性：
• This antibody detects endogenous levels of FBX22 at Human/Mouse

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1：500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 44kD

• 背景：
• This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010],

• 功能：
• function:Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.,similarity:Contains 1 F-box domain.,subunit:Directly interacts with SKP1A and CUL1.,tissue specificity:Predominantly expressed in liver.,

• 细胞定位：
• Cytoplasm, myofibril, sarcomere, Z line .

• 组织表达：
• Predominantly expressed in liver, also enriched in cardiac muscle.

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