• 靶点：
• MSMO1

• 简介：
• >>Steroid biosynthesis;>>Metabolic pathways

• 基因名称：
• MSMO1 DESP4 ERG25 SC4MOL

• 蛋白名称：
• MSMO1

• Human Gene Id：
• 6307

• Human Swiss Prot No：
• Q15800

• Mouse Gene Id：
• 66234

• Mouse Swiss Prot No：
• Q9CRA4

• Rat Gene Id：
• 140910

• Rat Swiss Prot No：
• O35532

• 免疫原：
• Synthesized peptide derived from human MSMO1 AA range: 212-262

• 特异性：
• This antibody detects endogenous levels of MSMO1 at Human/Mouse/Rat

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 32kD

• 背景：
• Sterol-C4-mehtyl oxidase-like protein was isolated based on its similarity to the yeast ERG25 protein. It contains a set of putative metal binding motifs with similarity to that seen in a family of membrane desaturases-hydroxylases. The protein is localized to the endoplasmic reticulum membrane and is believed to function in cholesterol biosynthesis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

• 功能：
• catalytic activity:3-beta-hydroxy-4-beta-methyl-5-alpha-cholest-7-ene-4-alpha-carbaldehyde + NAD(P)H + O(2) = 3-beta-hydroxy-4-beta-methyl-5-alpha-cholest-7-ene-4-alpha-carboxylate + NAD(P)(+) + H(2)O.,catalytic activity:4,4-dimethyl-5-alpha-cholest-7-en-3-beta-ol + NAD(P)H + O(2) = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholest-7-en-3-beta-ol + NAD(P)(+) + H(2)O.,catalytic activity:4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholest-7-en-3-beta-ol + NAD(P)H + O(2) = 3-beta-hydroxy-4-beta-methyl-5-alpha-cholest-7-ene-4-alpha-carbaldehyde + NAD(P)(+) + 2 H(2)O.,cofactor:Iron.,domain:The histidine box domains may contain the active site and/or be involved in metal ion binding.,pathway:Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 3/6.,similarity:Belongs to the sterol desaturase family.,

• 细胞定位：
• Endoplasmic reticulum membrane ; Multi-pass membrane protein .

CCR9 overexpression promotes T-ALL progression by enhancing cholesterol biosynthesis. Frontiers in Pharmacology Quiping Zhang WB Human 1:1000 JURKAT cell
货号：YT7443

miR-19b-3p Regulated by Estrogen Controls Lipid Synthesis Through Targeting MSMO1 and ELOVL5 in LMH Cells. POULTRY SCIENCE Hong Li WB Chicken LMH cell
货号：YT7443

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