• 靶点：
• ADCY5

• 简介：
• >>Purine metabolism;>>Metabolic pathways;>>Endocrine resistance;>>Rap1 signaling pathway;>>cGMP-PKG signaling pathway;>>cAMP signaling pathway;>>Chemokine signaling pathway;>>Phospholipase D signaling pathway;>>Oocyte meiosis;>>Longevity regulating pathway;>>Longevity regulating pathway - multiple species;>>Adrenergic signaling in cardiomyocytes;>>Vascular smooth muscle contraction;>>Apelin signaling pathway;>>Gap junction;>>Platelet activation;>>Circadian entrainment;>>Thermogenesis;>>Retrograde endocannabinoid signaling;>>Glutamatergic synapse;>>Cholinergic synapse;>>Serotonergic synapse;>>GABAergic synapse;>>Dopaminergic synapse;>>Inflammatory mediator regulation of TRP channels;>>Insulin secretion;>>GnRH signaling pathway;>>Ovarian steroidogenesis;>>Progesterone-mediated oocyte maturation;>>Estrogen signaling pathway;>>Melanogenesis;>>Thyroid hormone synthesis;>>Oxytocin signaling pathway;>>Regulation of lipolysis in adipocytes;>>Renin secretion;>>Aldosterone synthesis and secretio

• 基因名称：
• ADCY5

• 蛋白名称：
• ADCY5

• Human Gene Id：
• 111

• Human Swiss Prot No：
• O95622

• Mouse Gene Id：
• 224129

• Mouse Swiss Prot No：
• P84309

• Rat Gene Id：
• 64532

• Rat Swiss Prot No：
• Q04400

• 免疫原：
• Synthesized peptide derived from human ADCY5 AA range: 471-521

• 特异性：
• This antibody detects endogenous levels of ADCY5 at Human/Mouse/Rat

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1：500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 139kD

• 背景：
• This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010],

• 功能：
• catalytic activity:ATP = 3',5'-cyclic AMP + diphosphate.,cofactor:Binds 2 magnesium ions per subunit.,enzyme regulation:Inhibition by calcium in the submicromolar concentration range.,function:This is a membrane-bound, calcium-inhibitable adenylyl cyclase.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 2 guanylate cyclase domains.,

• 细胞定位：
• Cell membrane ; Multi-pass membrane protein. Cell projection, cilium .

• 组织表达：
• Detected in pancreas islets (at protein level). Detected in pancreas islets.

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