• 靶点：
• AL1L1

• 简介：
• >>One carbon pool by folate;>>Metabolic pathways

• 基因名称：
• ALDH1L1 FTHFD

• 蛋白名称：
• AL1L1

• Human Gene Id：
• 10840

• Human Swiss Prot No：
• O75891

• Mouse Gene Id：
• 107747

• Mouse Swiss Prot No：
• Q8R0Y6

• Rat Gene Id：
• 64392

• Rat Swiss Prot No：
• P28037

• 免疫原：
• Synthesized peptide derived from human AL1L1 AA range: 512-562

• 特异性：
• This antibody detects endogenous levels of AL1L1 at Human/Mouse/Rat

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1：500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 99kD

• 背景：
• The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012],

• 功能：
• catalytic activity:10-formyltetrahydrofolate + NADP(+) + H(2)O = tetrahydrofolate + CO(2) + NADPH.,similarity:Belongs to the aldehyde dehydrogenase family.,similarity:Contains 1 acyl carrier domain.,similarity:In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.,similarity:In the N-terminal section; belongs to the GART family.,

• 细胞定位：
• Cytoplasm, cytosol .

• 组织表达：
• Highly expressed in liver, pancreas and kidney.

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