• 靶点：
• PSDE

• 简介：
• >>Proteasome;>>Alzheimer disease;>>Parkinson disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Spinocerebellar ataxia;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Epstein-Barr virus infection

• 基因名称：
• PSMD14 POH1

• 蛋白名称：
• PSDE

• Human Gene Id：
• 10213

• Human Swiss Prot No：
• O00487

• Mouse Gene Id：
• 59029

• Mouse Swiss Prot No：
• O35593

• 免疫原：
• Synthesized peptide derived from human PSDE AA range: 152-202

• 特异性：
• This antibody detects endogenous levels of PSDE at Human/Mouse

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 34kD

• 背景：
• This gene encodes a component of the 26S proteasome. The 26S proteasome is a large multiprotein complex that catalyzes the degradation of ubiquitinated intracellular proteins. The encoded protein is a component of the 19S regulatory cap complex of the 26S proteasome and mediates substrate deubiquitination. A pseudogene of this gene is also located on the long arm of chromosome 2. [provided by RefSeq, Feb 2012],

• 功能：
• catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,function:Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear.,similarity:Belongs to the peptidase M67A family. PSMD14 subfamily.,similarity:Contains 1 MPN (JAB/Mov34) domain.,subunit:Component of the 19S regulatory cap of the 26S proteasome.,tissue specificity:Widely expressed. Highest levels in heart and skeletal muscle.,

• 细胞定位：
• proteasome complex,nucleus,nucleoplasm,cytosol,proteasome regulatory particle, lid subcomplex,proteasome accessory complex,cytosolic proteasome complex,extracellular exosome,

• 组织表达：
• Widely expressed. Highest levels in heart and skeletal muscle.

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