• 靶点：
• MPDZ

• 简介：
• >>Tight junction

• 基因名称：
• MPDZ MUPP1

• 蛋白名称：
• MPDZ

• Human Gene Id：
• 8777

• Human Swiss Prot No：
• O75970

• Mouse Gene Id：
• 17475

• Mouse Swiss Prot No：
• Q8VBX6

• Rat Gene Id：
• 29365

• Rat Swiss Prot No：
• O55164

• 免疫原：
• Synthesized peptide derived from human MPDZ AA range: 1564-1614

• 特异性：
• This antibody detects endogenous levels of MPDZ at Human/Mouse/Rat

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 228kD

• 背景：
• The protein encoded by this gene has multiple PDZ domains, which are hallmarks of protein-protein interactions. The encoded protein is known to interact with the HTR2C receptor and may cause it to clump at the cell surface. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015],

• 功能：
• similarity:Contains 13 PDZ (DHR) domains.,

• 细胞定位：
• Cell membrane; Peripheral membrane protein; Cytoplasmic side. Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, postsynaptic density. Cell projection, dendrite. Cell junction, tight junction. Cell junction, synapse. Cell junction, synapse, synaptosome. Colocalizes with HTR2C on the apical membrane of epithelial choroid plexus cells (By similarity). Highly enriched in postsynaptic densities (PSD). Localized to punctae on dendrites of hippocampal neurons and colocalizes with the synaptic marker DLG4. Localized mainly in the Schmidt-Lanterman incisures of myelinating Schwann cells (By similarity). In the retina, localizes to the sub-apical region adjacent to the adherens junction complex at the outer limiting membrane. Enriched at the tight junctions

• 组织表达：
• Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas.

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