• 靶点：
• TPC1

• 简介：
• >>Calcium signaling pathway

• 基因名称：
• TPCN1 KIAA1169 TPC1

• 蛋白名称：
• TPC1

• Human Gene Id：
• 53373

• Human Swiss Prot No：
• Q9ULQ1

• Mouse Gene Id：
• 252972

• Mouse Swiss Prot No：
• Q9EQJ0

• Rat Gene Id：
• 246215

• Rat Swiss Prot No：
• Q9WTN5

• 免疫原：
• Synthesized peptide derived from human TPC1 AA range: 104-154

• 特异性：
• This antibody detects endogenous levels of TPC1 at Human/Mouse/Rat

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1：500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 90kD

• 背景：
• Voltage-gated Ca(2+) and Na+ channels have 4 homologous domains, each containing 6 transmembrane segments, S1 to S6. TPCN1 is similar to these channels, but it has only 2 domains containing S1 to S6 (Ishibashi et al., 2000 [PubMed 10753632]).[supplied by OMIM, Mar 2008],

• 功能：
• domain:Each of the two internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.,function:May function as one of the major voltage-gated Ca(2+) channel (VDCC) across the plasma membrane.,similarity:Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.,subunit:Dimer .,tissue specificity:Highest expression found in the heart and kidney, and lowest expression found in the spleen.,

• 细胞定位：
• Lysosome membrane ; Multi-pass membrane protein . Endosome membrane ; Multi-pass membrane protein . Early endosome membrane ; Multi-pass membrane protein . Recycling endosome membrane ; Multi-pass membrane protein .

• 组织表达：
• Highest expression found in the heart and kidney, and lowest expression found in the spleen.

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