• 靶点：
• SESN3

• 简介：
• >>p53 signaling pathway;>>Longevity regulating pathway

• 基因名称：
• SESN3 SEST3

• 蛋白名称：
• SESN3

• Human Gene Id：
• 143686

• Human Swiss Prot No：
• P58005

• Mouse Gene Id：
• 75747

• Mouse Swiss Prot No：
• Q9CYP7

• 免疫原：
• Synthesized peptide derived from human SESN3 AA range: 35-85

• 特异性：
• This antibody detects endogenous levels of SESN3 at Human/Mouse

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 54kD

• 背景：
• This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012],

• 功能：
• caution:Positions 27 to 191 are in EST BF328700; positions 244 to 492 can be found in EST BG291497 but several frameshifts need to be corrected to restore the correct sequence. Positions 412 to 492 are in AF086251 with no conflicts.,similarity:Belongs to the sestrin family.,tissue specificity:Widely expressed.,

• 细胞定位：
• Cytoplasm .

• 组织表达：
• Widely expressed.

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