• 靶点：
• ERLN2

• 基因名称：
• ERLIN2 C8orf2 SPFH2 UNQ2441/PRO5003/PRO9924

• 蛋白名称：
• ERLN2

• Human Gene Id：
• 11160

• Human Swiss Prot No：
• O94905

• Mouse Gene Id：
• 244373

• Mouse Swiss Prot No：
• Q8BFZ9

• Rat Gene Id：
• 290823

• Rat Swiss Prot No：
• B5DEH2

• 免疫原：
• Synthesized peptide derived from human ERLN2 AA range: 239-289

• 特异性：
• This antibody detects endogenous levels of ERLN2 at Human/Mouse/Rat

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1：500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 37kD

• 背景：
• This gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012],

• 功能：
• function:Plays an important role in the early steps of the endoplasmic reticulum-associated degradation (ERAD) pathway. Involved in ITPR1 degradation by the ERAD pathway.,similarity:Belongs to the band 7/mec-2 family.,subcellular location:Associated with lipid raft-like domains of the endoplasmic reticulum membrane.,subunit:Interacts with activated ITPR1, independently of the degree of ITPR1 polyubiquitination.,tissue specificity:Ubiquitous.,

• 细胞定位：
• Endoplasmic reticulum membrane ; Single-pass type II membrane protein . Associated with lipid raft-like domains of the endoplasmic reticulum membrane.

• 组织表达：
• Ubiquitous.

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