• 靶点：
• TXD12

• 简介：
• >>Glutathione metabolism;>>Metabolic pathways

• 基因名称：
• TXNDC12 TLP19 UNQ713/PRO1376

• 蛋白名称：
• TXD12

• Human Gene Id：
• 51060

• Human Swiss Prot No：
• O95881

• Mouse Gene Id：
• 66073

• Mouse Swiss Prot No：
• Q9CQU0

• Rat Gene Id：
• 298370

• Rat Swiss Prot No：
• Q498E0

• 免疫原：
• Synthesized peptide derived from human TXD12 AA range: 118-168

• 特异性：
• This antibody detects endogenous levels of TXD12 at Human/Mouse/Rat

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1：500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 19kD

• 背景：
• This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. This protein localizes to the endoplasmic reticulum and has a single atypical active motif. The encoded protein is mainly involved in catalyzing native disulfide bond formation and displays activity similar to protein-disulfide isomerases. This protein may play a role in defense against endoplasmic reticulum stress. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Mar 2012],

• 功能：
• catalytic activity:2 glutathione + protein-disulfide = glutathione disulfide + protein-dithiol.,cofactor:FAD.,function:Possesses significant protein thiol-disulfide oxidase activity.,function:Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Extramitochondrial AIF induces nuclear chromatin condensation and large scale DNA fragmentation (in vitro). Binds to DNA in a sequence-independent manner.,similarity:Belongs to the FAD-dependent oxidoreductase family.,similarity:Contains 1 thioredoxin domain.,subcellular location:Translocated to the nucleus upon induction of apoptosis.,subunit:Interacts with XIAP.,tissue specificity:Widely expressed.,

• 细胞定位：
• Endoplasmic reticulum lumen .

• 组织表达：
• Widely expressed.

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