• 靶点：
• RIP

• 基因名称：
• RPAIN RIP

• 蛋白名称：
• RIP

• Human Gene Id：
• 84268

• Human Swiss Prot No：
• Q86UA6

• Mouse Gene Id：
• 69723

• Mouse Swiss Prot No：
• Q9CWY9

• Rat Gene Id：
• 287463

• Rat Swiss Prot No：
• Q4G2Y1

• 免疫原：
• Synthesized peptide derived from human RIP AA range: 117-167

• 特异性：
• This antibody detects endogenous levels of RIP at Human/Mouse/Rat

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 24kD

• 功能：
• function:Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism.,PTM:Isoform 2 is sumoylated. Sumoylation is required for localization in the nuclear PML body and transport of RPA complex in PML body. Upon UV irradiation and during S phase, it is desumoylated, releasing RPA complex that is translocated to sites of DNA damage. Sumoylation takes place at different Lys residues.,similarity:Contains 1 RIP-type zinc finger.,subcellular location:Only nuclear, localizes to PML body.,subunit:Interacts with the RPA1 subunit of RPA complex.,tissue specificity:Widely expressed. Expressed in pancreas, kidney, muscle, liver, lung, placenta, brain, heart, leukocytes, colon, intestine, ovary, testis

• 细胞定位：
• [Isoform 1]: Cytoplasm. Nucleus.; [Isoform 2]: Nucleus, PML body.

• 组织表达：
• Widely expressed. Expressed in pancreas, kidney, muscle, liver, lung, placenta, brain, heart, leukocytes, colon, intestine, ovary, testis, prostate, thymus and spleen.

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