• 靶点：
• EXOS1

• 简介：
• >>RNA degradation

• 基因名称：
• EXOSC1 CSL4 CGI-108

• 蛋白名称：
• EXOS1

• Human Gene Id：
• 51013

• Human Swiss Prot No：
• Q9Y3B2

• Mouse Gene Id：
• 66583

• Mouse Swiss Prot No：
• Q9DAA6

• 免疫原：
• Synthesized peptide derived from human EXOS1 AA range: 93-143

• 特异性：
• This antibody detects endogenous levels of EXOS1 at Human/Mouse

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1：500-2000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 21kD

• 背景：
• This gene encodes a core component of the exosome. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2016],

• 功能：
• domain:The N- and C-terminal regions of the protein are required for interaction with RRP46.,function:Component of the exosome 3'->5' exoribonuclease complex, a complex that degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions. Required for the 3'processing of the 7S pre-RNA to the mature 5.8S rRNA. Has a 3'-5' exonuclease activity.,similarity:Contains 1 S1 motif domain.,subunit:Component of the exosome multienzyme ribonuclease complex composed of at least 11 proteins: EXOSC1/CSL4, EXOSC2/RRP4, EXOSC3/RRP40, EXOSC4/RRP41, EXOSC5/RRP46, EXOSC6/MTR3, EXOSC7/RRP42, EXOSC8/RRP43, EXOSC9/Scl-75, DIS3/RRP44, and EXOSC10/Scl-100 (only in the nuclear complex). Interacts directly with EXOSC5, EXOSC6, EXOSC7 and EXOSC8. Also associated with the GTPase Ran.,

• 细胞定位：
• Nucleus, nucleolus . Nucleus . Cytoplasm .

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