• 靶点：
• PPIL1

• 简介：
• >>Spliceosome

• 基因名称：
• PPIL1 CYPL1 CGI-124 UNQ2425/PRO4984

• 蛋白名称：
• PPIL1

• Human Gene Id：
• 51645

• Human Swiss Prot No：
• Q9Y3C6

• Mouse Gene Id：
• 68816

• Mouse Swiss Prot No：
• Q9D0W5

• 免疫原：
• Synthesized peptide derived from human PPIL1 AA range: 73-123

• 特异性：
• This antibody detects endogenous levels of PPIL1 at Human/Mouse

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 18kD

• 背景：
• This gene is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved, ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. Based on similarity to other PPIases, this protein could accelerate the folding of proteins and might catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. [provided by RefSeq, Jul 2008],

• 功能：
• catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,enzyme regulation:Inhibited by Cyclosporin A.,function:PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing.,similarity:Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.,similarity:Contains 1 PPIase cyclophilin-type domain.,subunit:Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3,

• 细胞定位：
• Nucleus .

• 组织表达：
• Ubiquitous, with the most abundant expression in heart and skeletal muscle.

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