• 靶点：
• KIF5A

• 简介：
• >>Endocytosis;>>Dopaminergic synapse;>>Alzheimer disease;>>Parkinson disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Salmonella infection;>>Non-small cell lung cancer

• 基因名称：
• KIF5A NKHC1

• 蛋白名称：
• KIF5A

• Human Gene Id：
• 3798

• Human Swiss Prot No：
• Q12840

• Mouse Gene Id：
• 16572

• Mouse Swiss Prot No：
• P33175

• Rat Gene Id：
• 314906

• Rat Swiss Prot No：
• Q6QLM7

• 免疫原：
• Synthesized peptide derived from human KIF5A AA range: 213-263

• 特异性：
• This antibody detects endogenous levels of KIF5A at Human/Mouse/Rat

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 114kD

• 背景：
• This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport. Mutations in this gene cause autosomal dominant spastic paraplegia 10. [provided by RefSeq, Jul 2008],

• 功能：
• disease:Defects in KIF5A are the cause of spastic paraplegia type 10 (SPG10) [MIM:604187]. SPG10 is a form of autosomal dominant hereditary spastic paraplegia (AD-HSP). HSP is a group of inherited degenerative spinal cord disorders characterized by a slow, gradual, progressive weakness and spasticity (stiffness) of the legs. Rate of progression and the severity of symptoms is quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.,domain:Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coi

• 细胞定位：
• Cytoplasm, perinuclear region . Cytoplasm, cytoskeleton . Perikaryon . Concentrated in the cell body of the neurons, particularly in the perinuclear region. .

• 组织表达：
• Distributed throughout the CNS but is highly enriched in subsets of neurons.

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